The Institutional Review Board (IRB), part of the Human Research Protection Program, reviews all research involving humans to ensure that participants are informed of all known risks posed by a research study and that these studies are conducted in accordance with the ethical standards put forward by the Belmont Report, and federal, state, and local regulations, and policies governing human research.  Wake Forest University Health Sciences operates with four biomedical Institutional Review Boards that are supported by the IRB Office.


The Human Research Protection Program (HRPP) serves participants in human research by coordinating the safety, ethics and regulatory reviews of research projects. In addition, the HRPP oversees the conduct of research projects to ensure ongoing compliance with the approved protocol, federal regulation, state and local laws, and institutional policy.

The HRPP consists, in part, of:

  • Institutional Review Board
  • Office of Sponsored Programs
  • Medical Radiation Safety Committee
  • Institutional Conflict of Interest Office
  • Radioactive Drug Research Committee
  • Biosafety Committee
  • Comprehensive Cancer Center Protocol Review Committee
  • Clinical Research Unit
  • Clinical Trials Office
  • Investigational Pharmacy
  • Department-specific review committees
  • The study teams who carry out human research