Trifoil InSyTe microPET/CT Scanner
Located on the Ground Floor of the MRI Building, PET Center.
This new, high performance PET benchtop system with in-line X-ray CT provides the ability to visualize and quantify biological processes over a wide range of PET tracer activities with a reconstructed isotropic image resolution of <1.0µl (<1mm). The InSyTe Lab PET system is the first preclinical PET with continuous bed motion PET detection, maintains uniform signal-to-noise sensitivity across the entire scan range.
XtremeCT II HRpQCT
Located on the 1st floor of the MRI building.
High-Resolution peripheral Quantitative Computed Tomography (HRpQCT) Imaging – Wake Forest University School of Medicine was awarded an equipment grant (S10OD030295-01; PI: Ashley Weaver) to purchase a Scanco Xtreme CT II HRpQCT scanner (Southeastern, PA).
XtremeCT II hardware specifications include: 140 mm field of view; 210 mm maximum scan length; 4.2.1 p/mm (10% MTF) resolution; 70 μm isotropic default voxel size, with a nominal voxel size of 61 μm for patient scanning; 2048 x 2048 image matrix for default patient measurement; 4608 x 4608 maximal native image matrix; up to 10 mm stack height; 221 mm x 19.5 mm (or 4608 x 400 pixel) detector size. The x-ray tube has a voltage of up to 70 kVp DC (+/- 1%); 2 mA (+/- 1%) current; maximum power of 100 W; focal spot size of 60 μm; effective dose of 5 μSv and ~2 minutes measurement time per image stack (for default patient measurements). The scanner includes the following accessories: a density calibration phantom for quality control measurements, rolling chair and positioning casts for human subject scans.
The XtremeCT II system includes a software suite that offers a comprehensive solution for scanning, 3D analysis, visualization, image management, and data import/export. The measurement program included with the XtremeCT II system includes: image analysis tools (including IPL:Image Processing Language Package); bone density and morphometry; 3D image rendering and visualization; image output; data output; networking; and Scanco finite element analysis software. The scanner computer workstation specifications include: hp Integrity Server rx2800 (8x2.13 Ghz CPU); 128 GB RAM; 2 x 300 GB + 80 TB disk storage; 2 x 10/100/1000 Mb/s Ethernet; open VMS operating system; hp 24” tft monitor; LTO7 tape drive; GPU reconstruction hardware and software.
iThera MSOT Acuity
Located on the 1st floor of the MRI building
Multispectral Optoacoustic Tomography (MSOT) is a breakthrough optical functional imaging modality that uniquely enables non-invasive detection of optical contrast at high spatial resolution and centimeter-scale penetration depth in living tissue. MSOT captures a multitude of morphologic, metabolic, and pathophysiological tissue parameters in vivo by quantifying the contrast of endogenous tissue chromophores. With unique contrast and spatial resolution that is not attainable by conventional optical methods. Pulse-echo B-mode ultrasound is interleaved with the optoacoustic acquisition to provide structural information and assist in locating the region of interest in imaged tissue, creating a naturally co-registered dual-modality imaging system. Multispectral images (i.e., images acquired from several laser wavelengths) are unmixed to reveal the presence and distribution of various tissue chromophores, such as melanin, oxy-/deoxy-hemoglobin, collagen, lipids, and water. Through this approach, MSOT delivers information about oxygenation, inflammation, water, fat and collagen distribution, melanin concentration, and fibrotic changes in deep tissue.