PET Research Facility

Explore the many resources of the PET Research Facility

Index

Cyclotron | PET/CT Scanner | microPET/CT | Hot Cells | Quality Control | Other Services | Tracers

GE PETtrace 10 Cyclotron

PETtrace 10 Cyclotron

 

The GE PETtrace Radiotracer Production System is a compact, automated cyclotron and radiochemistry system designed for the fast, easy, and efficient production of PET radiotracers.  The PETtrace System is centered on a compact negative ion cyclotron of proven design.  The PETtrace Cyclotron features a vertical mid-plane and can accelerate protons to 16.5 MeV and deuterons to 8.4 MeV of energy.  The system can be configured with various targets/process systems for production of common PET radioisotopes.  The high performance, flexible design is ideal for applications in a research setting.

The PET isotopes, which can be produced by the PETtrace System, including oxygen-15, nitrogen-13, carbon-11, and fluorine-18, are automatically transferred to the radiochemistry processing systems for efficient conversion into finished radiotracers or precursors for use in preparing other labeled molecules.

GE 64-slice PET/CT Discovery MI DR ScannerPET CT 2

 

The new PET/CT Discovery MI DR Scanner has 24 detector rings that provide 47 contiguous image planes over a maximum 70 cm transaxial field of view with CT attenuation correction. Axial spatial resolution of this scanner is 3.27 mm at the center of the gantry. Data acquisition modes include static, dynamic, whole body, and gated. The room is equipped with anesthesia gases and exhaust for scavenging the gases. There is a dedicated viewing area to interpret scans and a data analysis room. In addition, a dedicated research PACS for PET has been created to store PET data in DICOM format (images and raw data).

The scanner has high-sensitivity, uniform spatial resolution across the whole field of view and includes a laser alignment system for accurate positioning. Advanced detector technology - BGO crystals (6.3 mm transaxial, 6.3 mm axial, 30 mm radial) for high sensitivity and photo-fraction. There are 10,080 individual cut crystals for efficient light detection arranged in 24 rings of 420 crystals each. Large detector ring produces uniform resolution important for whole body imaging, especially for lymph nodes under the arm and where skin lesions can be on distant parts of the body. Thick, long-bore collimators and end-shield caps reduce scatter and random events. Excellent electronics provide high bandwidth, and very high count rate capability with low dead time. Large display panel for easy monitoring with bilaterally placed control panels for easy access. The scanner has fast movement with simultaneous up/in or down/out with convenient foot pedals for up/down and accommodates patients that weigh up to 400 lbs.

This research-dedicated facility is equipped with all necessary supplies. There is a participant dressing and waiting area, and a CT-registered technologist performs the scanning. All image data is HIPAA compliant and can be networked (DICOM format) to GE workstations, TeraRecon servers, Mac workstations, or other servers for analysis by investigators.

Trifoil InSyTe microPET/CT Scanner

This new, high performance PET benchtop system with in-line X-ray CT provides the ability to visualize and quantify biological processes over a wide range of PET tracer activities with a reconstructed isotropic image resolution of <1.0µl (<1mm). The InSyTe Lab PET system is the first preclinical PET with continuous bed motion PET detection, maintains uniform signal-to-noise sensitivity across the entire scan range.

 Hot Cells

Transis-All In One

Fx2M

CyclotronGE PET Trace 800 Series

FxMel

GE TRACERlab FxC

 Quality Control

ProStar 210UV-Varian HPLC 

ProStar 210 UV-Varian HPLC

 Waters Alliance HPLC

Waters Alliance HPLC

 Agilent 7890BGas Chromatography

Agilent 7890B Gas Chromatography

 Radio TLC Scanner

Radio TLC Scanner

 Other Services

Daily Sterility testing

 BET testing of radiopharmaceuticals

BET testing of radiopharmaceuticals

Tracers

Tracer
Application
[11C]PiB Imaging brain amyloidosis for AD  
[18F]AV1451 Imaging Tau protein aggregates for AD
[11C]Nicotine (inhalation) Nicotine uptake in pulmonary pathways
[11C]Nicotine (injection) Nicotine uptake in brain
[11C]AcOAc Ketone uptake in brain activity
[11C]PBR28 Inflammation imaging
[11C]MPC-6827 Microtubule imaging
[11C]Raclopride Dopamine D2/D3 receptor binding
[11C]Fallypride Dopamine D2/D3 receptor binding
[11C]NOP1
 Nociceptin Opioid receptor imaging
[11C]Acetate Metabolic uptake imaging
[18F]MeFDG Sodium-glucose linked transporter-2 (SGLT2) imaging
[18F]UCBH Synaptic vesicle 2A (SV2A) imaging
[11C]MK-6884
Muscarinic cholinergic receptor 4 (M4) imaging
[11C]EKAP Kappa opioid receptor (KOR) imaging