CTSI Announcement

The Global Partnerships & Grand Challenges Team Announces Five New Grand Challenges Requests for Proposals

New Funding Opportunity

February 17, 2025

We are pleased to announce five new Grand Challenges (GC) requests for proposals (RFPs).We encourage you to apply to the Challenges for which you are eligible - and to share this email with others who may be interested.

The new RFPs include:

  1. "Innovations for Gram-Negative Antibiotic Discovery," a unique collaboration among three partners, the Novo Nordisk Foundation, Wellcome, and the Gates Foundation. Through this GC RFP, the partners are launching a new initiative, the Gram-Negative Antibiotic Discovery Innovator (Gr-ADI). Gr-ADI will bring together funders, research institutions, and industry partners to address the problem of anti-microbial resistance, now the third leading cause of death globally. This RFP serves as the source of Gr-ADI's first projects and is focused on the discovery of antibiotics with broad spectrum activity againstEnterobacteriaceae, usingKlebsiellaspp. as the pathogen to initiate a discovery program.
  2. "Accelerating Innovations to Address Heavy Menstrual Bleeding in Women in Low-Resource Settings"
  3. "Enhancing HIV and TB Diagnosis: Adjunct Technologies for Sample Collection and Processing"
  4. "Innovative Data and Modeling Approaches to Measure Women's Health"
  5. "Reducing the Burden of Preeclampsia"


We are planning a few webinars to provide more information and answer your questions about the RFPs being announced today. You can sign up for the sessions here:


Accelerating Innovations to Address Heavy Menstrual Bleeding in Women in Low-Resource Settings:


Enhancing HIV and TB Diagnosis: Adjunct Technologies for Sample Collection and Processing:


Innovations for Gram-Negative Antibiotic Discovery:


Reducing the Burden of Preeclampsia:


Like all Grand Challenges projects over 20-plus years, the newly announced RFPs will foster innovation to address urgent global priorities, and the grantees, funders, and others in the Grand Challenges network will work in the spirit of partnership to maximize their combined impact.

We invite you to read summaries of selected Grand Challenges grants, explore an interactive world mapof projects across the Grand Challenges network, and sign up on the Grand Challenges websiteto receive email updates like this one.